WebObstructive sleep apnea (OSA) is a heterogeneous and increasingly common disorder characterized by repetitive narrowing and collapse of the pharyngeal airway during sleep. 1 The main feature of OSA is chronic intermittent hypoxia (CIH), which is associated with conditions such as hypertension, metabolic disorders, and cancer. 2–4 The pathogenesis … WebJun 15, 2024 · Elevated Loop Gain as a Cause and Consequence of OSA Patients with OSA exhibit elevated loop gain that improves with nasal CPAP in small studies to date. 6, 11 – 13, 21, 24, 26 Of note, the calculation of loop gain may reflect upper airway dynamic effects in addition to changes in chemical drive.
American Journal of Respiratory and Critical Care Medicine
WebTo help classify patients into relevant prognostic and therapeutic categories, an OSA phenotype can be operationally defined as: “A category of patients with OSA distinguished from others by a single or combination of disease features, in relation to clinically meaningful attributes (symptoms, response to therapy, health outcomes, quality of … WebLoop gain is defined as the corrective respiratory response divided by the magnitude of the respiratory disturbance that produced the correction. A large respiratory response to a small perturbation corresponds to a high loop gain and significantly represents unstable respiratory control. duty calls betekenis
Patient Phenotyping in OSA SpringerLink
WebThe dynamic loop gain is assessed at a frequency of one cycle per minute (LG1) based on the kinetics of OSA ( 6, 7 ). Analysis is performed in 7-minute windows to allow the use of breath-by-breath uncalibrated ventilation. Median LG1 values from across the entire … WebAug 25, 2024 · During polysomnography (PSG), a central apneic event is conventionally defined as cessation of airflow for 10 seconds or longer without an identifiable respiratory effort. In contrast, an... WebAug 15, 2024 · Loop gain refers to the instability in the ventilatory control system; one component is sometimes referred to as mixing gain and includes circulatory delay. Classic studies by Guyton et al 8 demonstrated the development of Cheyne-Stokes breathing, a manifestation of high loop gain, with prolonged circulation in animals. in accordance with imi